University of St Andrews
 
 

School of Biology News Centre

item 78
[28-02-2008 to 28-03-2008]


News Item:
Discovery may assist future treatment of Alzheimer's

A St Andrews' researcher has identified a new protein associated with the progression of Alzheimer's disease. The discovery may assist in developing future treatments for the disease, which currently affects around 700,000 people in the UK.

Neurobiologist Dr Frank Gunn-Moore found that increased amounts of a protein called endophilin I are linked to increased stress in the brain, which subsequently leads to brain cell death. Dr Gunn-Moore said, "Endophilin I is known to be involved in how nerve cells talk to each other. Our research has identified additional roles for endophilin I that link it to being an indicator for the progression of Alzheimer's disease." The research also found that increased amounts of endophilin I were an indicator for the interaction between amyloid beta, and a protein called ABAD. Amyloid builds up in the brains of patients with Alzheimer's and other forms of dementia. It forms plaques which can lead to brain cell death that causes memory loss and other devastating symptoms of dementia. The Amyloid/ABAD interaction has been previously identified as a marker for the progression of Alzheimer's disease.

"We know very little about the early stages of Alzheimer's disease before the amyloid plaques are formed. It may be that production of amyloid beta is the earliest event in Alzheimer's disease, so identification of early markers for amyloid beta would have strong implications for the prevention and treatment of Alzheimer's disease," Dr Gunn-Moore explained.

The research was carried out by Dr Gunn-Moore and PhD student Yimin Ren, alongside a team of international researchers at the University of Columbia, USA, led by Professor Shi Du Yan. The study was funded by the Alzheimer's Research Trust and the Medical Research Council.

see here for further details
contact: Prof Frank Gunn-Moore


 

Biology News Archive:

Opportunities



Research Blog



Upcoming Events



Events
Biology, BSRC

  • 25-06-2015 at 16-00 - Seminar
    BSRC Virology Public Lecture
    Sir John Skehel and Professor Rob Webster
    Main Lecture Theatre, Medical Sciences Building

    25-06-2015 at 16-00 - Seminar
    BSRC Virology Public Lecture

    Sir John Skehel and Professor Rob Webster
    Main Lecture Theatre, Medical Sciences Building

    "The continuing threat of influenza."

    <p>During graduation week, Professor Rob Webster and Sir John Skehel will receive honorary degrees from the University in recognition of their outstanding contributions to our understanding of the epidemiology and molecular biology of influenza viruses. As part of the celebrations of their degrees, Professor Webster and Sir Skehel will give a joint public lecture on "the continuing threat of influenza" at 4.00pm on Thursday 25th of June in the Medical School lecture theatre. Host: Prof Rick Randall</p>

    prebooking: No
    audience: All staff and students, Alumni, Public
    contact: Professor Rick Randall




  • 19-06-2015 at 16-00 - Environment
    Bioblitz 2015
    Alfredo Ojanguren
    The Gatty Marine Lab, SOI, East Sands

    19-06-2015 at 16-00 - Environment
    Bioblitz 2015

    Alfredo Ojanguren
    The Gatty Marine Lab, SOI, East Sands

    Join our 24 hour effort to record biodiversity around the Gatty Marine Laboratory at East Sands. We&#8217;ll be sampling for birds, flies, bats, beetles, bugs, fish, plants, seaweed, molluscs and more. Events include rock pooling, bird walks, fish surveys, moth trapping&#8230; and they are all free and open to the public. Last year we recorded more than 500 species and we want to beat that this year.

    <p>Find out more information and regular up-dates visit our Facebook page</p>

    further details

    prebooking: No
    audience: All staff and students, Alumni, Committee members, Parents/guardians, Prospective students, Public
    contact: Alfredo Ojanguren




  • 17-06-2015 at 13-00 - Seminar
    BSRC Seminar Series
    Dr David Newman
    BMS Seminar room

    17-06-2015 at 13-00 - Seminar
    BSRC Seminar Series

    Dr David Newman
    BMS Seminar room

    Title to follow

    <p>Research seminar by Dr David Newman, National Cancer Institute, Maryland, USA.</p>

    further details

    prebooking: No
    audience: All staff and students
    contact: Dr Rebecca Goss




all University events | submit an event